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Description

The extrinsic pathway involves interaction of cell surface death receptors [for example, Fas/CD95

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Many active ingredients in TCM present issues like poor stability, solubility, and difficulty crossing the BBB, which restrict their use in treating depression effectively

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A separate 2025 review in SAGE Journals also evaluates the broader musculoskeletal evidence base

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Employing a higher value for the threshold factor k would impose a more stringent selection criterion, preferentially identifying reactions with the strongest linear correlation (R) between flux and predictive contribution

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