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and de Villartay, J-P

5.2 Antioxidants for tumors Malignant tumors are severe diseases caused by the uncontrolled and abnormal proliferation of cells

Since MLN4924 only affects cullin-dependent RING E3 ubiquitin ligases (Duda et al, 2008), but not RNF4, this data confirmed that CCW28-3 induced RNF4-independent degradation via a different but so far unidentified cullin-dependent RING E3 ligase