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Description

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

JAMA 311, 563

doi: 10.1146/annurev-pharmtox-010818-021637 76 CatrinaSBZhengX

Subsequently, H 2 O 2 can undergo decomposition into O 2 and H 2 O through the catalytic action of CAT or react with GSH in the presence of GPx, resulting in the formation of oxidized glutathione (GSSG) and water