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Since the mVCN of the cell product that was infused into these two patients was 1.9 and 2.1, the relatively low mVCN determined 24 months later in the peripheral blood of these two patients indicate that the modified cells may have failed to properly engraft, survive and/or produce -globin (and in consequence hemoglobin), and were therefore unable to meaningfully contribute to hematopoiesis and support correction of the disease

According to the expression of concern published on 8 May, the Editorial Board has decided to allow the authors to confirm the validity of the overall findings by performing re-experimentation on certain elements of this study. Lu did not respond to an emailed request for a comment about why the two studies were treated differently

Vitamin B6 is essential in numerous biochemical pathways involving red blood cells, the immune system, central nervous system function, protein metabolism, homocysteine metabolism, and also the production of energy

Wen PY, Schiff D, Cloughesy TF, Raizer JJ, Laterra J, Smitt M et al