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Methods: Gene expression was analyzed using RNA sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), and 10x spatial transcriptomics in primary human hepatic stellate cells (hHSCs) and a CCl4-liver fibrosis induced murine model

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All mice were housed under specific pathogen-free conditions at a controlled temperature of 2025C and 3575% humidity with a 12-h light/dark cycle and were provided sterile food and water ad libitum