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2527 In a meta-analysis of studies including the West of Scotland Coronary Prevention Study (WOSCOPS), Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), and Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) primary prevention trials, the relative risk reduction for those at high genetic risk was 46%, compared with 26% in all other participants ( P for heterogeneity = 0.05)

These beneficial commensals are typically depleted in ICU patients, with studies demonstrating reduced abundances of SCFA-producers such as Faecalibacterium , Blautia , and Bifidobacterium during critical illness (Lee et al., 2025)

There is growing evidence that ASD is associated with abnormalities in several metabolic pathways, including the inter-connected folate, methylation and glutathione pathways

2005 June 1096 (11):1145-51