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Arauz, J., Ramos-Tovar, E

PLoS One 12:e0183090

This process is further catalysed by the action of mitochondrial glutamine dehydrogenase (GDH), resulting in the conversion to -ketoglutarate (-KG)

For example, phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Ser727 has been shown to be an important node through which toll-like receptor 4 (TLR4) mediates metabolic reprogramming and promotes IL-1 production, thereby providing a new mechanistic entry point for integrating receptor signaling-metabolic flux-inflammatory output (136)