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These -cell characteristics make them vulnerable to destruction, and this is exacerbated in the pathogenic conditions of T1D and T2D, in which there are increased levels of pro-inflammatory cytokines, reactive oxygen species (ROS) and nitric oxide (NO), which are especially detrimental since -cells have limited antioxidant defense capabilities (42, 43), and are highly sensitive to cytokine mediated damage

doi: 10.7150/ijbs.59272 294 CarrouelFValetteMGadeaEEsparcieuxAIllesGLangloisMEet al

Wang Y, Lu X, Wang X, Qiu Q, Zhu P, Ma L, et al

It is found in practically every compartment of plant cells, including the chloroplasts, apoplast, mitochondria, cytosol, vacuole, peroxisomes, and endoplasmic reticulum, and predominantly in mitochondria in animal cells [18,24]