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Ethical Approval This article is based on previously conducted studies and does not contain new studies with human participants or animals performed by any of the authors

This autoimmune response results in the activation of special immune system cells (macrophages), which are responsible for repetitive blood vessel wall damage

It regulates cellular proliferation, metabolism, differentiation, and apoptosis for maintenance of the skin barrier and immune function.(1) Low vitamin D does not support skin healing, and is a major contributing factor to redness (rosacea), flaking, puffiness, acne, and tenderness

This conclusion is also supported by the presence of anti-S IgA in HCW who were seronegative for anti-S IgG at D21 and the loss of neutralizing activity for serum samples testing positive for anti-S or anti-RBD IgG, but negative for anti-S or anti-RBD IgA