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1457-C ASSESSMENT OF REGIONAL IMPACT ON THE PHARMACOKINETICS OF VIR-2218 (BRII-835) IN SUBJECTS WITH CHRONIC HEPATITIS B VIRUS INFECTION Yali Zhu 1 , Sneha Gupta 2 , Chunming Li 1 , Chong Zhu 1 , Xiaofei Chen 1 , Weihong Liu 1 and Ji Ma 1 , (1)Brii Biosciences, (2)Vir Biotechnology, Inc Background: VIR-2218 (also referred as BRII-835) is an investigational, N-acetylgalactosamine (GalNAc)conjugated RNA interference (RNAi) therapeutic that targets a region of the hepatitis B virus (HBV) genome that is common to all HBV viral RNA transcripts