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A 2022 study investigating berberines antimicrobial properties found that it slows bacterial metabolism, stops them from creating new cell walls and amino acids, and lowers their antioxidant levels.15 More recently, a 2024 review broadly confirmed that berberine has anti-pathological capabilities.52 And although much of the research on berberines impact on intestinal and gut microbiome health is still in progress, studies have supported the anecdotal evidence that berberine may be a potent anti-diarrheal agent.2 As an anti-inflammatory Berberines anti-inflammatory effects come into play through the modulation of multiple signaling pathways

The incidence of hematologic toxicities and neoplasia encountered in groups of renal homograft recipients is significantly higher than that in studies employing AZASAN for rheumatoid arthritis

Recently, mesoporous silica nanospheres (MSNs) as nano-carriers attracted much attention due to chemically modifiable surfaces, high surface area, characteristic nanostructure, biocompatibility and a large load capacity 32,33,34

Ethical approval was obtained from the Ethics Committee of Maternal and Child Health Care Hospital of Shandong Province, affiliated to Qingdao University