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In a healthy body, glutathione acts as the ultimate biological shield, protecting delicate cellular architecture from the constant threat of highly reactive molecules known as free radicals or reactive oxygen species (ROS)

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ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung

However, there is an interdependent relationship in which the NADPH pool is simultaneously supported and used by various pathways in cells