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Xia et al., 2020

The pharmacokinetic properties of a peptide are optimized using chemical modifications such as changing l-amino acids with d-amino acids, cyclization, conjugation (e.g., acylation, pegylation, glycosylation), amide bond protection (e.g., N-methyl groups), and incorporation of altered or unnatural amino acids (e.g., tert-butyl group on serin)

In yet another aspect, the invention provides methods of preventing weakness in a patient with Parkinson's disease and/or of improving or restoring muscle strength of a patient with Parkinson's disease

Tesofensine is an oral small-molecule triple monoamine reuptake inhibitor not a peptide developed for weight loss and studied in Phase 2 trials as a once-daily 0.5 mg capsule