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These complementary approaches, combined with advanced co-culture systems that partially reconstruct testicular cellular interactions, currently represent the most reliable in vitro tools for EED reproductive toxicity research

While these studies have started uncovering the impact of UC deficiency on HCC, many of them used cell culture, three-dimensional (3D) spheroids, and tumor cell transplantation systems, which do not faithfully recapitulate the unique metabolic and immunological features of the liver