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Epidemiological studies indicate that the lifetime prevalence of prostatitis-like symptoms in men ranges from 35% to 50%, with an annual prevalence of approximately 8%8.2%, being particularly common in men under 50 years of age ( In this context, accurately defining the disease phenotype of study subjects is crucial for elucidating pathological mechanisms

Toxicol Appl Pharmacol 116989 Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB)

4 Moreover, females exhibit a biologically distinct metabolic context from males, shaped by sex-specific physiological programs, including pregnancy and lactation, which involve profound shifts in lipid metabolism and carnitine demand, 8 which remain largely unexplored

The main practical cautions are its blue-green color (which can tint formulations) and formulation incompatibility with certain other actives notably strong direct-acid vitamin C and high concentrations of exfoliating acids, which can destabilize the copper complex