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Clinical trials have shown beneficial effects at doses of 10g daily

For people who cannot tolerate GI side effects or who have medical conditions that make GLP-1 agonists risky, this safety differential is not a minor footnote

Obesity(SilverSpring) 18(10):19021905 Fisher-Wellman KH, Ryan TE, Smith CD et al (2016) A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice