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We found significantly lower mean Tajimas D for the top SNPs from the GWAS compared with background SNPs for three of the four traits (Figure 8) due to an excess of low frequency alleles (i.e., low MAFs), consistent with purifying selection (Paape et al., 2013)

Rowe, Alzheimers Disease Neuroimaging Initiative, Alzheimers Disease Repository Without Borders Investigators, G

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(II) social cognition