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The amido group is used to activate the ribose backbone, using PRPP amidotransferase, the first committed step of de novo purine synthesis, as well as to produce carbamoyl phosphate in the first step of pyrimidine metabolism

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GH AND CARDIOVASCULAR CHANGES Extensive research has shown that adult GH deficiency (AGHD) is associated with low-grade inflammation, oxidative damage, a prothrombotic tendency, an impaired adipokine profile, subclinical left ventricular (LV) dysfunction, and metabolic syndrome (23)