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Insulin resistance, hyperinsulinemia, dyslipidaemia, and obesity precede the progression to T2D in 7585 % of patients [65], and the presence of MetS increases up to fivefold the risk for T2D compared to individuals without MetS [66, 67]

People with active or suspected cancer: Despite GHK-Cus anti-cancer potential, it theoretically could promote the formation of new blood vessels, which can feed tumors.3 9 14 People with anxiety or mood disorders: Similarly, although GHK-Cu has demonstrated an anxiolytic and anti-aggression effect in rats, the present research is too meager to support it as a viable treatment for anxiety or mood disorders

The University of Michigan also warns that a B12 shot is not recommended for people with Lebers disease (7)