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[DOI] [PubMed] Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, et al

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The Dual-Agonist Mechanism: How Zepbound Works Zepbound functions as a dual hormone receptor agonist , targeting: GLP-1 (Glucagon-like Peptide-1) Receptors: Regulates appetite and insulin production Reduces hunger signals from the brain Slows gastric emptying for prolonged fullness Improves blood sugar control GIP (Glucose-dependent Insulinotropic Polypeptide) Receptors: Enhances fat metabolism and insulin response Promotes efficient fat burning Supports better glucose utilization Works synergistically with GLP-1 for enhanced results The Twincretin Approach: This dual-receptor targeting explains how Zepbound works for weight loss more effectively than single-receptor medications like Wegovy