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10.1016/j.neuron.2015.06.005 Neuron 5 BalikiM

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Because of this, depletion of GSH is considered the primary step of ferroptosis [47]

In the presence of oxidative stress or specific electrophilic stimuli , critical cysteine residues on KEAP1 undergo modifications that disrupt KEAP1-mediated repression, resulting in the stabilization and release of Nrf2