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While negative PCNA immunohistochemical marker expression was significantly higher in group IV (GLP + CoQ group) (62.5%) than in group III (GLP group) (12.5%), and that confirms the shielding effect of CoQ on the thyroid tissue, especially when combined with GLP as it decreases cell proliferation and subsequently decreases the incidence of thyroid disorder or neoplastic transformation ( p = 0.030197) as illustrated in Table 7, and Fig