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60 NADPH oxidase, which is a major source of production of ROS in vessel walls, is activated in hypertensive rats

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Intracellular polyunsaturated fatty acids (PUFA) are catalyzed to produce phospholipid-polyunsaturated fatty acids (PL-PUFA), which can be peroxidized either enzymatically or nonenzymatically to form PLOOH ( Since ferroptosis is a result of an imbalance between oxidative and antioxidant oxidation in the cell, intracellular antioxidant factors, such as the GPX4 antioxidant system, are available to protect the cell from ferroptosis

Sometimes, people have diffuse idiopathic skeletal hyperostosis together with these other conditions