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This is in good agreement with data obtained by Aguila and collaborators who showed that inhibition of arrestin 2 expression reduces etorphine-induced hDOR endocytosis but not upon DPDPE or deltorphin I exposure (Aguila et al., As demonstrated for MOR and DOR, KOR also undergoes an arrestin-dependent sequestration when activated by U50,488 as shown by the reduction of internalization when the dominant negative mutant arrestin 2 319418 is over-expressed (Li et al., 1999)

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doi:10.1155/2014/682439 Cesarani A, Meloni F, Alpini D, Barozzi S, Verderio L, Boscani PF

Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy