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The phenolic hydroxyl group of E2, particularly on the A-ring, acts as a direct free radical scavenger by donating hydrogen atoms to neutralize ROS, thereby exerting non-enzymatic antioxidant effects (118)

Selenium What it does General Selenium is an essential trace mineral that is a structural component of several antioxidant enzymes and influences thyroid hormone function

171 Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, which increased tumor antigen cross-presentation to T cells and enhanced the efficacy of immune checkpoint blockade (ICB)

By binding copper with an affinity similar to albumins transport site, GHK can shuttle copper to cells and influence local copper availability