Devido a essas modificaes, o IGF-1 LR3 amplamente estudado em pesquisas que investigam processos de crescimento celular, diferenciao muscular, reparo tecidual e regulao metablica
In endothelial cell models, BPC-157 enhanced ERK1/2 phosphorylation in a dose-dependent manner, increasing cellular proliferation, migration, and vascular tube formation via downstream transcription factors c-Fos, c-Jun, and EGR-1
Studies looking into doses at or above 1,000mg/day reveal increasing adverse effects in a dose-dependent manner, including increases in biomarkers related to cardiovascular disease.7 Those side effects also included:8 Nausea Flatulence Abdominal discomfort Diarrhea Other GI issues Another study looking at a daily 5g dose of a patented form of resveratrol designed to increase bioavailability saw high rates of adverse effects, including two deaths among patients with bone marrow cancer.9 One of those deaths is suspected to have been caused by the disease itself, and the other is credited to this particular resveratrol formulation, which has lost research funding and will not come to market
Urgert R, Katan MB
