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Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded

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[The vast majority of the early travelers came from the settlements near the Missouri River who left the river in the Spring when dangers of snow had passed, and traveling by wagon, cart, or mule (more durable than horses) they moved westward.] There were four major routes by sea: paddle steamer (or occasionally sailing ship) to the future countries of Panama, Nicaragua or Mexico, a trip across land to the Pacific and then a trip by paddle steamer to California

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