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The Bottom Line Suppose you suffer from conditions that lead to B12 deficiencies or already have a deficiency

However, it has been recently described that mTORC2 also possesses tyrosine phosphorylation capacity [118], and that it phosphorylates tyrosines on IRS and tyrosine kinases in both receptors, IGF-1 and IR, thus reinstituting the signal of the activated receptors [118]

Some of the most common causes include: Low levels of zinc (zinc deficiency) Radiation or surgery around the head and neck Dry mouth Changes in oral cavity flora Infection (example: COVID-19) Mucositis Platinum chemotherapy (cisplatin (Platinol), carboplatin (Paraplatin)) Anthracycline chemotherapy (example: doxorubicin (Adriamycin) Other chemotherapy agents (examples: cyclophosphamide (Cytoxan), 5-fluorouracil (5-FU)) Oral chemotherapy (example: sunitinib (Sutent), vismodegib (Erivedge)) Antihistamines How to prevent Altered Taste Preventing dysgeusia in patients with cancer can be challenging since it is a side effect of cancer treatment

These cases, supplemented with a literature review, highlight the potential for biologic drug-induced vitiligo and underscore the need for awareness of such adverse events in clinical practice