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Trials in Europe were more likely to include patients in the 1417 age range

In AIPN, multiple detrimental pathways involving oxidative stress and leading to neuronal damage from free radicals and inflammatory cytokines have been described [31,32]

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S34HYP mutation markedly decreased the peptide affinity for amylin receptor 1 ECD by 9-fold, when compared to the peptide affinity with S34P mutation (Figure 2E and Table 2)