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One clinical trial involving a large cohort of patients with mild to moderate AP, obesity, and IR found that metformin treatment led to significant decreases in fasting blood glucose levels, 2-hour postprandial glucose levels, and HOMA-IR scores, alongside improvements in lipid profiles ( Thiazolidinediones, such as rosiglitazone and pioglitazone, have also been used to treat AP patients with metabolic syndrome and IR