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To maximize the effectiveness of the treatment, glutathione is usually used together with other powerful antioxidants

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doi:10.2353/ajpath.2008.070429 Dinic S, Arambasic J, Mihailovic M, Uskokovic A, Grdovic N, Markovic J, Karadzic B, Poznanovic G, Vidakovic M (2013) Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of alpha-lipoic acid in diabetic liver

Visible improvements usually appear within 812 weeks, with continued enhancement over several months