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In the United States, the Food and Drug Administration (FDA) classified BPC-157 as Category 2 for compounding due to adverse immune system reactions, peptide-related impurities and insufficient safety information to determine whether it would cause harm when administered to humans

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IGF-1 reduces serum GH levels (via somatostatin negative feedback in the pituitary) which in turn suppresses GH actions in the liver, thus enhancing insulin actions in this organ [165]

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