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In metabolic disorders, modulation of the PPP can help restore metabolic balance

Deficient glutathione may affect the ability of B12 to participate in metabolic functions, which in turn affects both the methylation cycle and the folate cycle

A Mendelian randomization study from European cohorts confirmed a causal link between TGs, cholesterol levels, and depression phenotypes, indicating that these metabolic factors may bridge the connection between T2DM and depression, potentially mediating their association (256)

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine