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& Verster, P

Neurotherapeutics 19 , 17241732 (2022)

That longer action is part of why maintenance injections can be spaced months apart rather than weeks

In prolonged vasoplegia, the vasoconstrictive effect of intrinsic hormones (adrenaline, noradrenaline, arginine vasopressin, and angiotensin II) is reduced through a combination of hormone depletion, desensitization of adrenergic receptors, and smooth muscle cell hyperpolarisation [12]