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Zhang Z-X

Weeks 13 through 16: 12mg weekly (full maintenance dose) The final escalation step brings you to the maximum dose tested in phase 2 trials

Research Use Notice All compounds referenced are intended strictly for laboratory research use only

Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]