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Advise pregnant women using opioids for an extended period of time of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available [see PRECAUTIONS, Information for Patients/Caregivers, Pregnancy]

While not a traditional IgE allergy, it is a T2-high response that occurs in ~7% of asthma patients.[ref] Smoking-induced asthma: Just like it sounds cigarette smoking can be a major cause of asthma

doi: 10.1016/j.biopha.2018.06.159 104 El-BabaCMahadevanVFahlbuschFBRauTTGali-MuhtasibHSchneider-StockR

If youre more tolerant to caffeine, or you want this supplement to supplant your coffee- or tea-drinking habit, you could also reach for the version that contains 200mg caffeine and 100mg L-theanine