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But the enzyme responsible for making urobilin was a mysteryuntil recently

These findings establish the ROS/GSK3/GPX4 axis as a key driver of CO-induced ferroptosis, but how this pathway intersects with other cell-death pathways remains to be clarified

This involves moving beyond simplistic exogenous scavenging to focus on enhancing intrinsic defense systems (e.g., Nrf2, JAK2/STAT3), leveraging novel drug delivery systems for targeted intervention, and exploring multi-target therapies

Panax notoginseng saponins (PNS), for example, have been shown in rats and rabbits to reduce atherosclerotic plaque development via multiple pathways