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One hard rule: keep this away from SSRIs or MAOIs without talking to your doctor first

Because mtDNA depletion or OXPHOS impairment profoundly alters redox state, membrane potential, ATP production, and metabolite distribution between mitochondria and cytosol [80], mitochondrial dysfunction can act as a source of epigenetic perturbation interventions that selectively inhibit OXPHOS complexes or mitochondrial carrier transporters can therefore help define the molecular identity of these mitochondria-derived epigenetic cues

Mainly extracellular fluid losses occur in hypotonic dehydration, where signs of dehydration easily become profound

2024;9(1):e0067223