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The p38 MAPK inhibitor SB239063 alleviates I/R-induced lung injury by reducing IL-1 expression[43]

Inflammatory mediators, including tumor necrosis factor-alpha and several interleukins, may contribute to fever, chills, muscle pain, changes in blood pressure, and temporary worsening of symptoms

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The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G