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A systematic review/meta-analysis including a total of 55 studies carried out in 17 different countries reported an overall prevalence estimated at 62% and a prevalence of around 24% in particular for severe periodontitis [16]

This may be attributed to the loss of survival signals from the matrix in the non-permissive ECM

Such elevation in intracellular calcium and the probable activation of PKC are suggested to culminate in the observed exocytosis of vesicles containing growth hormone from pituitary cells