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QW: Writing original draft

SGS may modify critical cysteine residues of Keap1, leading to Nrf2 stabilization and activation of the ARE, inducing phase 2 enzymes

Oxidative stress is involved in the pathogenesis of many diseases, including cancer, cardiovascular disease, arthritis, diabetes, influenza-like symptoms, and some lung disorders such as pulmonary oxygen toxicity, adult respiratory distress syndrome, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis [4], and cystic fibrosis

Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to efalizumab