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The C677T polymorphism (NCBI SNP cluster ID rs# 1801133) in MTHFR gene results in an alanine-to-valine (A222V) substitution which in turn causes a reduction in enzyme activity and subsequent elevation of plasma homocysteine [15, 16]

Co-trimoxazole is a US Food and Drug Administration-approved drug consisting of two antifolates, trimethoprim and sulfamethoxazole, which are on the list of the World Health Organization essential medicines that have been used as effective antimicrobial agents for over 40 years [34, 70]

Taken together, BSL helped to change the metabolism of BCAAs in the intestine, and might contribute to converting them to glutamine, but which bacteria had these functions deserved further study

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