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Description

The divergent structures of the BBB in rodents and humans complicate the extrapolation of preclinical data to humans (Hoshi et al., 2013)

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Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis

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Heart rate changes Increased heart rate has been noted as a potential side effect of cagrilintide, consistent with observations across the broader class of weight loss medications

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But half-life and duration of effect are different things

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