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The pathway centers on the interaction between Wnt ligands and the Frizzled/LRP co-receptor complex, leading to abnormal accumulation of -catenin in the nucleus and the expression of multiple transcriptional targets, including genes responsible for proliferation (e.g., MYC), anti-apoptosis (e.g., BIRC5), epithelial-mesenchymal transition (e.g., Snail), invasion (e.g., MMP), angiogenesis (e.g., VEGF), and inflammation (e.g., IL-6) (101)

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Integr Med (Encinitas) 13:3543 Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health

This chromatic alteration gives the augmented chord its characteristic dissonant sound: a sense of unresolved, ambiguous tension that is different from the pull of a dominant or the instability of a diminished chord