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3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)

8,9 Hyperphosphorylated tau detaches from microtubules and sticks to other tau molecules, generating threads that eventually unite to create tangles inside neurons, known as NFTs

This aligns with the perspective that single-target interventions may disrupt metabolic network homeostasis and activate compensatory pathways 60

10.1523/JNEUROSCI.3968-04.2004 150 YangC.WangC.WangM.QinX.HaoG.KangM.et al (2021)