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A standard curve of defined kynurenine concentrations (0100 M) was established to analyze unknown concentrations [24]

Acta Physiol Plant 36, 8599

One investigated topic is the impact on glutathione (GSH) and glutathione disulphide (GSSG) 18,19,20

Notably, Erastin-induced GSH depletion also promotes cardiolipin peroxidation, which not only triggers the opening of the mitochondrial permeability transition pore but also induces caspase-dependent and -independent apoptosis [218, 220,221,222]