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Paradoxically, however, reduced expression of specific mitophagy regulators, including PRKN [58] and BNIP3 [60], has been linked to worse prognosis in PDAC, underscoring the limitations of monogenic biomarkers in reflecting the functional state of mitophagy

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Proton Pump Inhibitor (PPI): Acts by inhibiting the proton pump in the stomach lining, thereby reducing acid production

11 Although each group assigned a different name to the protein (FRAP, 8 RAFT1, 9 or RAPT1 10 ), the term mTOR 11 for mammalian target of rapamycin ultimately became the accepted standard in mammals and other eukaryotes