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Statements Author contributions XY and JY wrote the manuscript

Symptoms include: fever cough chest pain shortness of breath wheezing fatigue difficulty swallowing bad breath excessive sweating Chronic obstructive pulmonary disease (COPD) Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease caused by alveolar (air sac) and airway damage

Even under androgen deprivation therapy, androgen levels are sufficiently high to activate overexpressed AR, which is due to intratumoral in-situ synthesis 141 and residual synthesis in the adrenal gland 142 , along with decreased levels of the androgen inactivating enzymes CYP3A4, CYP3A5, and CYP3A7 in patient tissue samples 143

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