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To ensure consistency and reliability, all assessments at each time point will be conducted by two independent, calibrated central assessors who are blinded to treatment allocation and are not involved in any clinical aspect of the trial

However, some people take clonidine to enhance the effects of methadone and other substances

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On the fourth day I developed a slightly sore throat, swollen lymph nodes in neck, continued fatigue, and mild intermittent abdominal pain