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Moreover, other proinflammatory proteins such as iNOS and TNF are also released from M1 cells (53, 175, 176) and contribute to neurodegeneration in PD (177)

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doi:10.1038/aja.2011.64

Native IGF-1 exists predominantly bound to IGF-binding proteins (IGFBPs) in circulation, which sequester the growth factor and limit its bioavailability to target tissues